Topic: Mitochondrial Health

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  Pyruvate Dehydrogenase Deficiency – Mitochondrial Dysfunction and Lactate Production
  Pyruvate Dehydrogenase is central to cellular energy production. Learn about its role in energy production, genetic mutations, association with ME/CFS and Long Covid, and strategies to manage its deficiencies.
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  Mold Genes: How mold and mycotoxins interact with genetics
  Exposure to certain kinds of mold can cause chronic, negative health effects. Discover how genetic variants impact the ability to handle mycotoxins.
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  Creatine: Boosting Muscles and Increasing Brain Power
  Creatine is an amino acid used in muscle tissue and the brain for energy in times of stress. Genes play a role in creatine synthesis. Find out what the research shows about creatine supplements for muscle mass and cognitive function.

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Topic: Hormones

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  HPA Axis Dysfunction: Understanding Cortisol and Genetic Interactions
  Cortisol is a hormone produced by the adrenal glands in times of stress, and it also plays many roles in your normal bodily functions. It is a multi-purpose hormone that needs to be in the right amount (not too high, not too low) and at the right time. Your genes play a big role in how likely you are to have problems with cortisol.
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  Thyroid Hormones: Genes, Hypothyroidism, and T4/T3 Conversion
  The thyroid is a master regulator controlling many of your body’s systems. It is integral for metabolism and body temperature. Learn more about specific thyroid-related variants and check your genetic raw data.
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  Estrogen: How It Is Made and How We Get Rid of It
  Estrogen – from how much is made to how it is broken down – is dependent on both genetics and lifestyle factors and affects both men and women. This article explains how estrogen is made, how it is eliminated from the body, which genes are involved, and how this influences the risk of breast cancer, prostate cancer, and fibroids.

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Topic: Supplements & Genes

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  HMB Supplement and Muscle Mass
  HMB – hydroxymethylbutyrate – is a supplement that helps to prevent muscle loss in aging and may help with building muscle when working out.
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  DAO Enzyme Supplements: Research Studies and Genetic Connections
  DAO enzyme supplements work by providing the enzyme needed to break down histamine in food and from the gut microbiome.
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  Which Type of Choline Works Best with Your Genes?
  Choline is an often neglected nutrient essential to a healthy diet. Your genes are important in how much and which types of choline you need.

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Topic: Nutrigenomics – Vitamins and Diet

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  Manganese: Genetic Interactions, Diet, and Supplements
  Manganese is an essential mineral needed in the right amount. It is important for health as an antioxidant cofactor, but too much is neurotoxic.
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  Are You Getting Too Much Folate?
  Folate is an essential vitamin with many benefits from getting an adequate amount. However, excess folate from high dose supplements may have potentially detrimental effects.
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  Histamine Intolerance: Genetic Report, Supplements, and Real Solutions
  Genetics plays a big role in how well your body breaks down histamine. You can use your genetic data to figure out if your genes are part of the reason why you have histamine intolerance.

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Topic: Disease Prevention

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  Aspirin, Colon Cancer Prevention, and Genetics
  For some people with specific genetic variants, aspirin may help to prevent colon cancer. Learn more about what the research says and check your genes.
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  Specialized Pro-resolving Mediators (SPMs): The Resolution of Inflammation
  Chronic inflammation is at the root of all diseases. New research discusses how pro-resolving mediators are the key to the resolution of inflammation.
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  Parkinson’s Disease: Genetics plus Environmental Factors
  Parkinson’s disease (PD) is not yet fully understood. Researchers think that it is caused by a combo of genetics and environmental factors. Learn more about this disease and the factors that lead to susceptibility.

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Topic: Inflammation / Immune Response

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  Fibromyalgia: Underlying causes and genetic connections
  Learn about the potential causes of fibromyalgia, including inflammation, genetics, and hypersensitivity to pain, along with overlapping conditions that complicate diagnosis.
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  Specialized Pro-resolving Mediators (SPMs): The Resolution of Inflammation
  Chronic inflammation is at the root of all diseases. New research discusses how pro-resolving mediators are the key to the resolution of inflammation.
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  Asthma Genes: Understanding your genetic pathways
  Genes and environmental factors combine to cause asthma. Learn how your genes impact the pathways involved in the different types of asthma.

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Topic: Mood and Brain

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  OCD: Obsessive-Compulsive Disorder Genes
  Genetic variants play a role in susceptibility to obsessive-compulsive disorder. Understanding your genes may help you understand OCD better and help you to target the right treatment.
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  HPA Axis Dysfunction: Understanding Cortisol and Genetic Interactions
  Cortisol is a hormone produced by the adrenal glands in times of stress, and it also plays many roles in your normal bodily functions. It is a multi-purpose hormone that needs to be in the right amount (not too high, not too low) and at the right time. Your genes play a big role in how likely you are to have problems with cortisol.
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  ADHD: Causes, Neurochemistry, and How to Check Your Genetic Raw Data
  Discover the complex interplay of genetics and environment in ADHD susceptibility. Learn how circadian rhythm and neurotransmitter genes contribute to the disorder, and how toxicant exposure may increase risk.

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Topic: Detoxification & Medications

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  CYP2J2: Arachidonic Acid, Inflammation, and Heart Disease
  The CYP2J2 gene is important in the metabolism of arachidonic acid into either pro- or anti-inflammatory lipid signals.
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  Mold Genes: How mold and mycotoxins interact with genetics
  Exposure to certain kinds of mold can cause chronic, negative health effects. Discover how genetic variants impact the ability to handle mycotoxins.
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  Glyphosate Exposure: Genetics and the Impact on Our Health
  Glyphosate is the active ingredient in the herbicide Round-Up. A recent study showed that people with CYP1A1 genetic variants are more likely to have problems with acetylcholinesterase inhibition from glyphosate.

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Topic: Heart Health

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  Salt Sensitivity and High Blood Pressure
  Genetic variants significantly influence individual salt sensitivity, with certain genotypes making people more prone to high blood pressure in response to high salt intake
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  Homocysteine: Genetics, High Homocysteine Levels, and Solutions
  High homocysteine levels are strongly linked to an increased relative risk of cardiovascular diseases. Find out how your genes impact homocysteine levels.
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  Niacin and Heart Disease: Genetic Interaction
  Higher intake of niacin, along with certain genetic variants, has been shown to increase the risk of heart disease. Check your SNPs here.

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Topic: Autoimmune Diseases

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  Thyroid Hormones: Genes, Hypothyroidism, and T4/T3 Conversion
  The thyroid is a master regulator controlling many of your body’s systems. It is integral for metabolism and body temperature. Learn more about specific thyroid-related variants and check your genetic raw data.
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  HLA B27: Genetic Variant That Increases Susceptibility to Autoimmune Diseases
  The HLA-B27 serotype is linked to an increased risk of several autoimmune diseases, including ankylosing spondylitis, psoriatic arthritis, and IBD.
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  Leaky Gut Genes: Emulsifiers in Processed Foods
  Emulsifiers, found in many processed and packaged foods, can trigger an inflammatory response in the intestines based on whether you carry specific genetic variants.

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Topic: Methylation Cycle Genes

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  Are You Getting Too Much Folate?
  Folate is an essential vitamin with many benefits from getting an adequate amount. However, excess folate from high dose supplements may have potentially detrimental effects.
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  AHCY Gene: Tying together methylation and homocysteine
  AHCY is a key gene in the conversion of SAH to homocysteine and in the regulation of the SAM/SAH ratio. It also plays an important role in the circadian regulation of gene expression.
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  Homocysteine: Genetics, High Homocysteine Levels, and Solutions
  High homocysteine levels are strongly linked to an increased relative risk of cardiovascular diseases. Find out how your genes impact homocysteine levels.

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Topic: Longevity / Healthspan

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  HMB Supplement and Muscle Mass
  HMB – hydroxymethylbutyrate – is a supplement that helps to prevent muscle loss in aging and may help with building muscle when working out.
• 
  Aspirin, Colon Cancer Prevention, and Genetics
  For some people with specific genetic variants, aspirin may help to prevent colon cancer. Learn more about what the research says and check your genes.
• 
  Parkinson’s Disease: Genetics plus Environmental Factors
  Parkinson’s disease (PD) is not yet fully understood. Researchers think that it is caused by a combo of genetics and environmental factors. Learn more about this disease and the factors that lead to susceptibility.

More in Longevity / Healthspan >>>

Topic: Circadian Rhythm and Sleep

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  Melanopsin: Light response, circadian rhythm, and blue light exposure
  Melanopsin is the receptor for blue light. It is found in the retina, skin, adipose tissue, and blood vessels. Genetic variants can impact reaction to blue light.
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  Histamine, Mast Cell Activation, and Early Morning Insomnia
  Histamine rising in the early morning hours may cause early waking insomnia. Mast cells and circadian rhythm disruption at the root.
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  Restless Leg and Periodic Limb Movement Disorder: Genes and Solutions
  Many know the frustration of disrupted sleep due to RLS and periodic limb movement disorder (PLMD). Genes play a role in your risk for these disorders, and there are specific research-based treatments to explore.

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Topic: Metabolic Health

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  Picking the Right Weight Loss Diet for Your Genes
  Is there an easy way to compare what diet might be best based on your genotype? Research shows some interesting associations between genotype and diet interactions and weight loss.
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  Adenoviruses: Causing Weight Gain and Obesity
  There have been several interesting studies linking obesity to a viral infection, specifically an adenovirus. Learn more about this virus and its association with obesity.
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  Insulin Resistance and Genetics: Finding the Root Cause
  Genetics combined with diet causes insulin resistance. While dietary sugar can be involved, genetic research points to BCAAs as having a causal role in IR.

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Topic: Traits

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  Dyslexia: Genes + Early Life Stressors
  While dyslexia is known to run in families, the role of genetics in dyslexia is still being determined. Here is a quick look at some of the genes involved in dyslexia, affecting around 10% of the population.
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  Mosquito Bite Genes: Are you a mosquito magnet?
  Do you feel like you are a magnet for mosquitoes? Genetic variants do play a role in how attractive you are to mosquitoes.
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  Will you go bald? Genetics and hair loss
  What causes male pattern baldness? A combination of genetics, nutrition, and environmental toxins come together to form the risk factors for baldness. But genetics really seems to rule the roost here.

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Topic: Pregnancy / Infertility

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  Trying to get pregnant? Targeted Approaches to Improving Egg Quality
  Trying to get pregnant? Healthy eggs are vital for a successful pregnancy. Discover four key ways to improve your egg quality, according to research studies.
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  Folate Optimization: MTHFR and Fertility
  MTHFR variants affect the conversion of folate into the active form. Learn how this can affect you if you are trying to get pregnant.
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  Genetic Causes of Male Infertility
  Almost 10% of couples worldwide struggle with infertility. Learn more about your genetic susceptibility and dig deeper into the lifestyle factors that could affect your sperm.

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