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Longevity

Learn how YOUR genes impact longevity and healthspan, and then apply the research-based Lifehacks to optimize your health and prevent the diseases of aging.

Where to start?

Members: Check out the Longevity Topic Summary Report for a quick overview of all your genetic variants related to longevity.
HMB for muscle growth, HMB for to prevent age related muscle loss, HMB caution with autoimmune diseases

HMB Supplement and Muscle Mass

HMB – hydroxymethylbutyrate – is a supplement that helps to prevent muscle loss in aging and may help with building muscle when working out.

Parkinson's Disease genetic factors and environmental factors, Parkinson's symptoms

Parkinson’s Disease: Genetics plus Environmental Factors

Parkinson’s disease (PD) is not yet fully understood. Researchers think that it is caused by a combo of genetics and environmental factors. Learn more about this disease and the factors that lead to susceptibility.

APOE type, APOE4 + Alzheimer's, Alzheimer's prevention

Alzheimer’s Gene: Find your APOE type from your genetic raw data

The APOE gene variants are linked with the risk of Alzheimer’s disease. Find out whether you carry the APOE risk type for Alzheimer’s – and learn what research shows about supplements and lifestyle changes to prevent this disease.

Nicotinamide riboside and NMN - Boosting NAD+ in aging

Nicotinamide Riboside and NMN: Boosting NAD+ in Aging

Explore the research about how nicotinamide riboside (NR) and NMN are being used to reverse aging. Learn about how your genes naturally affect your NAD+ levels and how this interacts with the aging process.

Taurine research on healthspan, longevity

Taurine: Research on Healthspan and Supplements

Taking a deep dive into the science behind taurine – from antiaging supplement to heart and digestive health. Genetics plays a role in who may benefit most from supplemental taurine.

SIRT3, Aging, and Mitochondrial Function

How we age is just as important as how long we live. Examine how sirtuins play a part in the aging process by how they regulate our cellular health.

Skin Aging: Using genomics to solve wrinkles and age spots

Some people age naturally with beautiful-looking skin. Others slather on creams and odd gunk in a futile battle to chase away wrinkles and age spots. What is the difference? Genetics and environmental factors, of course.

picture of natural supplements with a dollar sign

Guide: Saving Money on Supplements

Five quick examples of how you could use your genetic data to dial in the supplements worth trying and which ones to skip for now.

Longevity Genes: Hacking healthspan using genomics

Several genes have been identified as longevity genes, linked to an increase in lifespan. Most importantly, these particular genetic variants show links to a longer ‘healthspan’. Check your genetic data to see if you carry the FOXO3A and IGF1R variants associated with healthy longevity.

Rapamycin, mTOR, and Your Genes

Rapamycin is an antibiotic used as an immunosuppressant, an anti-cancer agent, and to prevent blocked arteries. Rapamycin is now the focus of longevity and healthspan-extending research by inhibiting mTOR.

Genetic Mutations (variants) that protect against alzheimers, strategies for reducing alzheimer's

Genetic Mutations that Protect Against Alzheimer’s Disease

Just like there are genetic variants that increase the risk of Alzheimer’s, there are also variants that protect against this disease. Check your genetic data to get a better picture of your risk factors. (Member’s article)

TREM2 Gene and Alzheimer’s Disease Risk, role of TREM2 in microglia autophagy, ways to increase TREM2

TREM2 and Alzheimer’s Disease Risk

The TREM2 gene is important in how the brain’s immune system functions. Learn how variants in this gene impact the risk for Alzheimer’s disease.

Age-Related Macular Degeneration Genes

Age-related macular degeneration (AMD) is the most common cause of blindness in the elderly. You will find supplements specifically promoted for preventing AMD. This article explains age-related macular degeneration, delves into the genetic risks, and then explains which supplements are likely to be protective and which may do more harm than good.

Nitric Oxide Synthase (NOS3): Heart health, blood pressure, and healthy aging

Nitric Oxide Synthase is an important signaling molecule in the endothelium of our blood vessels. It has roles in the regulation of blood pressure, cardiovascular disease, brain health, and more. Genetic variants in nitric oxide genes are important for a healthy heart. Find out how your genes could play a part in the interactions with cardiovascular disease risk and blood pressure.

Melatonin: Key to Health and Longevity

More than just a sleep hormone, melatonin is at the heart of many health topics. Your genetic variants play a big role in the production of melatonin. Learn how your lifestyle and diet interact with your melatonin-related genes.

Hemochromatosis Symptoms, genetics

Building Up Iron: Hemochromatosis mutations

A couple of common mutations can cause you to build up iron, leading to iron overload or hemochromatosis. It is one genetic disease where knowledge is really powerful – you can completely prevent hemochromatosis through blood donations.

Longevity Summary Report

Utilize our Longevity Topic Summary Reports with your 23andMe or AncestryDNA genetic data to see which articles may be most relevant to you. These summaries are attempting to distill the complex information down into just a few words. Please see the linked articles for details and complete references. (Member’s article)