| Gene | RS ID | Effect Allele | Your Genotype | Notes About Effect Allele |
|---|---|---|---|---|
| COMT | rs4680 | A | -- | GG = higher activity; AG=Intermediate activity AA = lower activity |
| COMT | rs4633 | T | -- | CC = higher activity ; TT = lower COMT activity |
| COMT | rs6267 | T | -- | Minor decrease in COMT |
| COMT | rs165599 | A | -- | Minor decrease in COMT |
| COMT | rs165774 | A | -- | lower COMT activity; more likely to have irrational beliefs if subjected to maltreatment in childhood |
Understanding your data:
If you have COMT rs4680 GG, you likely have faster (higher) COMT enzyme function.
If you have COMT rs4680 AG, you likely have intermediate COMT enzyme function (highlighted in yellow).
If you have COMT rs4680 AA, you likely have slow (lower) COMT enzyme function (highlighted in orange).
The rs4633 genotype usually is inherited in conjunction with rs4680. It is included here in case your genetic data file didn’t contain rs4680.
The additional COMT variants (rs6267 and rs165599) can add a little to your individual variation in COMT function.
Background science:
The catechol-O-methyltransferase (COMT) gene plays a critical role in the metabolic breakdown of catechols, including neurotransmitters dopamine, epinephrine, and norepinephrine, estrogen metabolites, and other substances with a catechol structure. COMT is crucial in controlling neurotransmitter levels and protecting cells from oxidative stress. The process involves the use of a methyl group, changing one substance to another, such as serotonin into melatonin.
COMT and Supplement Interactions:
Supplements that inhibit COMT function include natural flavonoids such as quercetin, fisetin, luteolin, rutin, and oleacein. COMT is also used in the metabolism of EGCG, although its inhibitory effect on COMT in humans is less clear. Such interactions typically require high levels found in supplements.
Alternative Supplements:
For those with low COMT function seeking natural anti-inflammatory supplements that don’t interact with COMT, consider Berberine, Resveratrol, Melatonin, and Hesperidin.
Methyl-Donor Supplements and COMT:
COMT requires methyl groups for its reactions. Increasing methyl donors via high-dose supplements can enhance COMT reactions. However, adding a lot of methyl donors may affect mood in people with slow COMT. Methyl donor supplements include SAMe (s-adenosylmethionine), Methylfolate, Methylcobalamin (methylB12), and TMG/betaine.
COMT Fast Enzyme Function:
In individuals with fast COMT, methyl donors may be utilized more quickly. Depending on the situation, adding methyl donors may be beneficial.
The Impact of Stacking Methyl Donors with COMT Inhibitors:
Stacking may cause mood alterations due to rapid changes in neurotransmitter levels, particularly in those with low COMT enzyme function.
Full article on COMT Supplement Interactions with links to peer-reviewed studies.
Disclaimer: This report is for informational and educational purposes only. It is not intended to treat, diagnose, or cure any condition.