FTO and m6A Methylation
Recently, researchers discovered that FTO is an m6A eraser that removes methyl groups from mRNA. This discovery has opened up huge avenues of research on topics from cancer to immune response to heart disease.
Disease Prevention
Your genes interact with your diet and lifestyle to influence your susceptibility to diseases. You can use your genetic data here in a couple of ways:
- Find the root cause: If you are dealing with a health condition, learn how to use your genetic data to get to the right solutions.
- Be proactive: Find out what you are genetically more susceptible to and what to do to prevent it.
Where to start in Disease Prevention?
- Top 10 Genes to Check
- Migraines: Genetics, causes, and pathways to target
- Specialized Pro-resolving Mediators and Resolving Chronic Inflammation
- Pancreatitis and Exocrine Pancreatic Insufficiency
Members: Check out the Disease Prevention Topic Summary Report for a quick overview of all your genetic variants related to disease prevention.
Articles and Genotype Reports ▼
Building Up Iron: Hemochromatosis mutations
A couple of common mutations can cause you to build up iron, leading to iron overload or hemochromatosis. It is one genetic disease where knowledge is really powerful – you can completely prevent hemochromatosis through blood donations.
PCSK9: Cancer Recurrence & Prevention
Lower PCSK9 levels have been shown in research studies to correlate to a significantly reduced risk of metastatic recurrence in certain types of cancer.
Gut Mucosal Barrier: Foundational and Underappreciated
Your gut mucosa protects you from microbes in the gut, your own digestive enzymes, and toxins from the environment. Learn what you can do to keep your gut mucosal barrier healthy.
Pyruvate Dehydrogenase Deficiency – Mitochondrial Dysfunction and Lactate Production
Pyruvate Dehydrogenase is central to cellular energy production. Learn about its role in energy production, genetic mutations, association with ME/CFS and Long Covid, and strategies to manage its deficiencies.
Aspirin, Colon Cancer Prevention, and Genetics
For some people with specific genetic variants, aspirin may help to prevent colon cancer. Learn more about what the research says and check your genes.
Parkinson’s Disease: Genetics plus Environmental Factors
Parkinson’s disease (PD) is not yet fully understood. Researchers think that it is caused by a combo of genetics and environmental factors. Learn more about this disease and the factors that lead to susceptibility.
Gilbert’s Syndrome: A Genetic Disorder Causing High Bilirubin
Gilbert’s syndrome is an inherited condition where the body doesn’t break down bilirubin efficiently. Discover the benefits of higher bilirubin levels in this syndrome and some possible risks.
BH4: Tetrahydrobiopterin Synthesis, Recycling, and Genetic SNPs
Tetrahydrobiopterin (BH4) is an essential cofactor in the production of neurotransmitters and nitric oxide. Genetic variants impact BH4 levels which can affect heart disease, cognitive function, and immune response.
Alzheimer’s Gene: Find your APOE type from your genetic raw data
The APOE gene variants are linked with the risk of Alzheimer’s disease. Find out whether you carry the APOE risk type for Alzheimer’s – and learn what research shows about supplements and lifestyle changes to prevent this disease.
Fibronectin, Genetics, and Alzheimer’s Prevention
Genetic variants in FN1 that reduce fibronectin also protect against Alzheimer’s in people with APOE E4. Here’s how to check your genes.
BRCA1 and BRCA2 Mutations: Interactions with Environment, other Genetic Variants
Women with BRCA1/2 mutations may face additional risk from certain environmental toxins or other genetic variants.
Back Pain: Genetics, Root Causes, and Solutions
For some people, back pain is a daily occurrence that drastically affects their quality of life. For others, it may be an intermittent nagging problem, often without rhyme or reason. Your genes play a role in whether disc degeneration gives you back pain.
Top 10 Genes to Check in Your Genetic Raw Data
Wondering what is important in your raw genetic data? Check out this list of 10 genes in your 23andMe or AncestryDNA data.
Fragile X Syndrome
Fragile X Syndrome is a genetic disorder that can cause changes in a person’s ability to learn and causes alterations in behavior. It is caused by mutations in the FMR1 gene.
Wilson’s disease: ATP7B Gene Mutations and Copper Accumulation in the Brain
Mutations in ATP7B can cause copper dysregulation and Wilson’s disease. People carrying one copy of the mutation may also have subtle changes.
COMT in Pain Disorders
Genetic polymorphisms in COMT affect how we feel certain types of pain. These variants are linked to increased susceptibility to chronic pain disorders.
Malignant Hyperthermia: RYR1 Gene Mutations and Anesthesia
Malignant hyperthermia is a serious reaction to inhaled anesthetics caused by rare mutations in the RYR1 gene.
Ehlers Danlos Syndrome: Genes, Types, and Treatments
Ehlers-Danlos Syndromes causes changes in the way that collagen forms in the joints, ligaments, and skin. Explore the research on EDS and the genetic mutations that cause some of the subtypes of the disorder.
Pancreatitis: Genetics, causes, and exocrine pancreatic insufficiency
Genetic variants that increase inflammation also increase the risk of pancreatitis. Learn about causes and natural solutions for pancreas problems.
Dental Implants: Genetics & Reducing the Risk of Implant Failures
Are you considering a dental implant? Failure rates of dental implants are fairly low but still carry some risk. Genetic variants can influence the likelihood of long-term success.
Lymphedema: Causes and Genetic Pathways
Lymphedema can be caused by various factors such as a traumatic injury, genetics, or even cancer. Discover how your genetics influence the risk of developing the condition.
Are Cold Sores Genetic? Who gets them and why
While many people carry the HSV virus, only about 30% will get cold sores. Genetics is one reason.
Alcohol Addiction: Exploring the Genetic and Environmental Factors
Discover the role of genetics, stress, and neurotransmitters in alcohol use disorder. Alcohol dependence is complex; understand your genes and the research on treatment options.
BChE gene: Nightshade sensitivity, Anesthesia risk
Genetic variants of the BChE gene decrease its enzyme’s activity. This can lead to various and seemingly unconnected consequences…such as an increased risk for Parkinson’s or food sensitivity to potatoes.