Genetic variants influence our immune response, affecting both our ability to combat pathogens and our susceptibility to chronic inflammation. For example, we are all unique in our response to different pathogens. Certain variants in inflammatory cytokine genes, such as TNF-alpha, may increase susceptibility to chronic inflammatory conditions while at the same time increasing your ability to fight off specific viruses or bacteria.
You can use your genetic data to understand which pathways are likely involved for you, and then use the lifehacks sections to discover the right solution for your genes.
Where to start?
Summary Reports for Members:
| Inflammation Summary | Immune System Summary Report |
Mannose-binding lectin, also known as mannose-binding protein, is involved in the body’s innate defense against infections. Find out how genetic variants in this system increase your susceptibility to specific pathogens.
IL-2 dysregulation affects long COVID, autoimmune diseases, and cancer therapy response. Learn about your IL-2 genetic variants and natural ways to support IL-2.
Learn which immune, mitochondrial, and genetic pathways—NK cells, NLRP3, interferon, complement, TRP channels, and more—may increase susceptibility to ME/CFS.
Learn how IL-15 influences NK cells and CD8+ T cells in the immune response to pathogens and cancers. Find out how your genetic variants influence IL-15 levels.
T cell exhaustion reduces immune function in chronic infections, long Covid, and cancer. Explore evidence-based natural interventions, and understand the mechanisms.
Trigger points are hyperirritated knots in the muscle and fascia that can refer pain to a nearby region of the body.
Chronic inflammation is at the root of all diseases. New research discusses how pro-resolving mediators are the key to the resolution of inflammation.
Epstein-Barr virus (EBV) impacts lifelong health, links to autoimmune diseases, genetic risk factors, and practical steps to reduce reactivation.
Mast cells are essential to your innate immune system, defending against pathogens and allergens. For some people, mast cells can be triggered too easily, giving allergy-like responses to lots of different substances.
Genetics plays a big role in how well your body breaks down histamine. You can use your genetic data to figure out if your genes are part of the reason why you have histamine intolerance.
Discover how genetics, triggers, and personalized strategies shape migraine prevention and relief. Find actionable solutions based on your DNA.
Are you more genetically susceptible to the flu? Learn how your genes play a role and discover research-backed natural options to beat the flu.
Hidradenitis suppurativa is caused by overactive inflammation and hyperkeratosis. Genetics plays a big role – along with environmental factors.
Learn about the potential causes of fibromyalgia, including inflammation, genetics, and hypersensitivity to pain, along with overlapping conditions that complicate diagnosis.
Genes and environmental factors combine to cause asthma. Learn how your genes impact the pathways involved in the different types of asthma.
Explore NLRP3 inflammasome genetics: How variants drive chronic inflammation in Alzheimer’s, diabetes, and autoimmune diseases. Discover triggers, health risks, and lifehacks like zinc & vitamin D to modulate it.
Rosacea is a chronic inflammatory skin condition that is driven by upregulated inflammation. Learn how your genes interact with environmental factors to cause rosacea.
Alpha-gal syndrome causes allergic reactions to meat (beef, pork, lamb) after being bitten by a tick. Find out why and which genetic pathways are involved.
For some people, back pain is a daily occurrence that drastically affects their quality of life. For others, it may be an intermittent nagging problem, often without rhyme or reason. Your genes play a role in whether disc degeneration gives you back pain.
Take a deep dive into the causes of chronic inflammation and learn how to target specific inflammatory pathways to reverse or prevent chronic disease.
Long Covid is the persistence of symptoms after having COVID-19. Learn more about the underlying causes and treatments backed by the newest research.
Explore the research-backed strategies for preventing or managing respiratory illnesses. Don’t let a cold get you down this year.
MRGPRX2 is a recently discovered mast cell receptor. It is linked to drug hypersensitivity reactions as well as asthma, rosacea, and IBD.
Inflammation and breakdown of cartilage are at the root of osteoarthritis. Learn how your genes impact the pathways involved in arthritis.
Genetic polymorphisms in COMT affect how we feel certain types of pain. These variants are linked to increased susceptibility to chronic pain disorders.