Genetic variants influence our immune response, affecting both our ability to combat pathogens and our susceptibility to chronic inflammation. For example, we are all unique in our response to different pathogens. Certain variants in inflammatory cytokine genes, such as TNF-alpha, may increase susceptibility to chronic inflammatory conditions while at the same time increasing your ability to fight off specific viruses or bacteria.
You can use your genetic data to understand which pathways are likely involved for you, and then use the lifehacks sections to discover the right solution for your genes.
Where to start?
Summary Reports for Members:
| Inflammation Summary | Immune System Summary Report |
Do you know of someone with unexplained heart palpitations, spiking blood pressure, dizziness, and tinnitus? Discover how research is linking these symptoms to histamine, mast cells, and the spike protein.
Alopecia areata is an autoimmune-like disorder in which the immune system attacks the hair follicle. Learn about the triggers of alopecia areata, why the hair falls out, genetic variants that increase susceptibility, and possible treatment options.
The CCR5 gene is an important player in the immune response. The CCR5-delta32 variant can reduce susceptibility to certain HIV strains, particularly in people with two copies.
Genetics plays a role in the susceptibility to antibiotic allergies. Learn which genetic variants increase your risk.
Will you get side effects from mRNA vaccines? A genetic variant in the HLA-A gene might cause an increase in your response to the vaccine.
Have you ever wondered why some people never seem to get the flu when it is going around? Simply put, some people are just more susceptible to getting the flu than others. Learn more and see if you are more or less susceptible to the flu.
In recent research, mutations in TLR7 (a sensor in our innate immune system) might cause severe Covid-19 in a small minority of healthy people.
Is the MTHFR mutation is a reason not to get the covid vaccine? Learn more with a look into the research behind MTHFR mutations and vaccines.
People who carry the genetic mutations that cause G6PD deficiency are at an increased risk for hemolytic anemia when taking quinine-based medications. This article is intended to be a ‘heads up’ for anyone who is considering using quinine or chloroquine without a doctor’s advice for COVID-19.
Inclusion body myositis is a progressive, chronic condition that causes muscle weakness. It may be an interplay between inflammation, the dysregulation of proteins, mitochondrial dysfunction, and changes to autophagy. Somewhere in the mix, autoimmunity may be triggering it.
The HMGB1 protein has a unique role in activating the inflammatory response pathways. Increased HMGB1 levels will call up the troops for a big response to an infection. Discover how genetic variants of this protein vary the risk of cancer, inflammation, and sepsis to name a few.
Vitamin D is more than just a ‘vitamin’. It is actually a hormone essential to many processes in your body – including your immune system. Learn how vitamin D helps the immune response to coronavirus, flu, and other respiratory viruses.
Genetics plays a role in both Meniere’s disease and tinnitus. Understanding your genetic susceptibility may help point you to the right solutions.
Genetics plays a huge role in how an individual responds to a vaccine. Learn more about vaccines, immunity, and genetic variants that affect the response.
Kawasaki disease is an excessive inflammatory response that some children have due to viral or bacterial illnesses. Several genetic variants are tied to an increased susceptibility to Kawasaki disease.
ARDS is caused by an overwhelming immune response to a virus, bacteria, or lung injury. Learn more about which of your immune system genes are involved in ARDS.
Your circadian rhythm influences your immune response. Learn how this rhythm controls white blood cell production and why melatonin protects against viral and bacterial infections.
Viral immunity-your genes protect you. Your genetic variants shape your immune system and give you superpowers against some pathogens, perhaps more susceptible to others.
Chronic inflammation is the driver of many common diseases such as heart attacks, diabetes, obesity, and autoimmune diseases. C-Reactive Protein is a marker of inflammation. Genetic variants can increase or decrease CRP levels.
Learn how your gut microbiome influences the expression of your core circadian rhythm genes.
Allergies are usually due to a mix of genetic susceptibility and being exposed to certain triggering molecules. Several different gene variants have ties to an increased risk of grass pollen allergies.
Histamine plays several important roles in the body. Learn more about the newest research into histamine intolerance and mast cells.