Resilience: Genetic Variants Involved in Surviving Childhood Trauma

Exposure to childhood trauma, such as exposure to abuse, violence, or repeated stress, can have a long-lasting effect. Adults exposed to childhood trauma have higher rates of depression, PTSD, suicide, and anxiety disorders.

The question that researchers have attempted to answer is: Why are some people resilient to childhood trauma while others have lifelong effects. Genetics is a big part of that answer. For some, childhood trauma causes physiological changes that last a life time.

Background on cortisol:

The HPA axis:

The HPA axis (hypothalamic-pituitary-adrenal axis) may play an integral role in the resilience to stress. Several studies have investigated the role of the HPA axis, childhood adversity, and adult depression or anxiety.[ref] One study concluded, “A history of childhood trauma has long-standing effects on adulthood cortisol responses to stress, particularly in that depressed individuals with a history of childhood trauma show blunted cortisol responses”.[ref]

The HPA axis is basically the interactions and feedback loops between the brain (hypothalamus) and the pituitary and adrenal glands. It regulates things like mood, energy, body temperature, and immune function — as well as the body’s release of cortisol in response to stress.

Related Article: HPA Axis Dysfunction and Genetics

Corticotropin-releasing hormone:

The production of Corticotropin-releasing hormone (CRH) occurs in the hypothalamus. CRH, in turn, activates ACTH (adrenocorticotropic hormone). ACTH controls the synthesis of cortisol, mineralocorticoids, and DHEA.  So it is a pathway that starts in the brain and ends with the release of hormones, such as cortisol from the adrenal glands.

For example, CRH release increases anxiety, suppresses appetite, and increases attention – just what you need when a tiger is chasing you, but not good when it is chronically a little elevated. Cortisol levels naturally rise and fall over the course of the day, in rhythm with your body’s circadian clock. There can be a cascade of chronic effects if this rhythm is either out of phase or dampened.

CRH also activates the corticotropin-releasing hormone receptor, CRHR1. Several, quite common genetic variants of CRHR 1 seem to interact with childhood trauma. Depending on the genotype, these variants can either increase or decrease the likelihood of long-term effects.

These genetic differences might indicate why some adults have lasting problems with cortisol (or ‘adrenal fatigue’) if exposed to traumatic events in childhood – or had chronic stress in their childhood. Or, to put it the opposite way, these variants are why some adults have no long-term problems from childhood trauma.

Genetic variants:

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CRHR1 genetic variants:

The two genetic variants listed below are ‘linked’; meaning, if you inherit one of them, you are very likely to have the other one also. One is covered on the v4 chip from 23andMe (prior to Aug. 2017), and the other is covered on the newer, v5, data from 23andMe.

Check your genetic data for rs242924 (23andMe v4; AncestryDNA):

  • G/G: increased risk of depression, anxiety due to childhood trauma[ref][ref]
  • G/T: somewhat increased risk of depression, anxiety due to childhood trauma.
  • T/T: no increase in the risk of depression, anxiety due to childhood trauma.

Members: Your genotype for rs242924 is .

Check your genetic data for rs110402 (23andMe v5; AncestryDNA):

  • G/G: increased risk of depression, anxiety due to childhood trauma[ref][ref]
  • A/G: somewhat increased risk of depression, anxiety due to childhood trauma.
  • A/A: no increase in the risk of depression, anxiety due to childhood trauma.

Members: Your genotype for rs110402 is .


Talk to your doctor:

If you carry the risk variants and deal with depression or anxiety, talk with your doctor about getting your cortisol levels tested to see if your levels are lower than normal or chronically high.


Herbal adaptogens, such as ashwagandha and Rhodiola, have been shown to modulate the body’s stress response system, including corticotropin-releasing hormone.[ref] Both are readily available at health food stores. (Read more about ashwagandha research)

Holy Basil, also called tulsi tea, has been shown to inhibit cortisol release by acting on the CRHR1 receptor.[ref] Check your local grocery store for tulsi tea / Holy Basil tea or get it online.

Sleep and Circadian rhythm:

If you have too much corticotropin receptor hormone at night, it can cause sleep problems and disrupt circadian rhythm.[ref] This can feed back into more stress, more cortisol release. Keeping a consistent sleep schedule and a good sleeping environment should help.

  • block blue light for 2 hours before bed (blue blocking glasses or turn off electronics)
  • sleep in a dark room
  • cool off at night
  • don’t eat within a few hours of bedtime, if possible
  • get morning sunlight
  • stick to a consistent sleep/wake schedule, even on weekends

Related Genes and Topics:

Cortisol and HPA Axis Dysfunction
Cortisol is a hormone produced by the adrenal glands in times of stress, and it also plays many roles in your normal bodily functions. It is a multi-purpose hormone that needs to be in the right amount (not too high, not too low) and at the right time. Your genes play a big role in how likely you are to have problems with cortisol.

Tryptophan is an amino acid that the body uses to make serotonin and melatonin. Genetic variants impact the amount of tryptophan used for serotonin. This can influence mood, sleep, neurotransmitters, and immune response.

Is inflammation causing your depression or anxiety?
Research over the past two decades clearly shows a causal link between increased inflammatory markers and depression. Genetic variants in the inflammatory-related genes can increase the risk of depression and anxiety.

Lithium Orotate + B12: Boosting mood and decreasing anxiety, for some people…
For some people, low-dose, supplemental lithium orotate is a game-changer for mood issues when combined with vitamin B12. But other people may have little to no response. The difference may be in your genes.

About the Author:
Debbie Moon is the founder of Genetic Lifehacks. Fascinated by the connections between genes, diet, and health, her goal is to help you understand how to apply genetics to your diet and lifestyle decisions. Debbie has a BS in engineering and also an MSc in biological sciences from Clemson University. Debbie combines an engineering mindset with a biological systems approach to help you understand how genetic differences impact your optimal health.