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Snips about SNPs: Diabetes and TCF7L2

Diabetes is usually blamed on eating the wrong foods, but your genes play a big role in your susceptibility to the disease.

The TCF7L2 (transcription factor 7-like 2) gene codes for a protein that activates many genes involved in type 2 diabetes,  including glucagon-like peptide 1 GLP1. Genetic variants are associated with a decreased or impaired beta-cell function. It is one of the best-studied genes with regard to diabetes risk.[ref][ref]

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Check your genetic data for rs7903146 (23andMe v4, v5; AncestryDNA):

  • T/T: 2-fold increased risk of diabetes, decreased beta-cell function[ref][ref]
  • C/T: increased risk of diabetes
  • C/C: typical

Members: Your genotype for rs7903146 is .

Check your genetic data for rs12255372 (23andMe v4, v5; AncestryDNA):

  • T/T: increased risk of diabetes[ref][ref]
  • G/T: increased risk of diabetes
  • G/G: typical

Members: Your genotype for rs12255372 is .

Want to learn more about genetics and diabetes risk factors? Check out this article!

 

*SNP stands for Single Nucleotide Polymorphism, which is when one of the nucleotide bases (the A, C, G, or Ts) is replaced by a different nucleotide base in a gene. 

Want more quick bits about your genes? Read through all the Snips about SNPs

 


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About the Author:
Debbie Moon is the founder of Genetic Lifehacks. Fascinated by the connections between genes, diet, and health, her goal is to help you understand how to apply genetics to your diet and lifestyle decisions. Debbie has a BS in engineering from Colorado School of Mines and an MSc in biological sciences from Clemson University. Debbie combines an engineering mindset with a biological systems approach to help you understand how genetic differences impact your optimal health.