FTO and m6A Methylation
Recently, researchers discovered that FTO is an m6A eraser that removes methyl groups from mRNA. This discovery has opened up huge avenues of research on topics from cancer to immune response to heart disease.
methylation
Vitamin B6: Genetics, Absorption, and Deficiency
Vitamin B6 is an important co-factor in hundreds of different enzymatic reactions. Low levels of B6 are linked to an increased risk of diabetes, cardiovascular disease, neurodegenerative diseases, and cancer. B6 is also essential for reducing oxidative stress and inflammation.
Histamine Intolerance: Genetic Report, Supplements, and Real Solutions
Genetics plays a big role in how well your body breaks down histamine. You can use your genetic data to figure out if your genes are part of the reason why you have histamine intolerance.
Which Type of Choline Works Best with Your Genes?
Choline is an often neglected nutrient essential to a healthy diet. Your genes are important in how much and which types of choline you need.
MTHFR Mutation: What is it? How to check your raw data.
The MTHFR gene is important for how your body utilizes folate (vitamin B9) for creating neurotransmitters, detoxifying toxicants, and maintaining a healthy heart. Check your 23andMe or AncestryDNA data for the MTHFR C677T and A1298C variants.
Creatine: Boosting Muscles and Increasing Brain Power
Creatine is an amino acid used in muscle tissue and the brain for energy in times of stress. Genes play a role in creatine synthesis. Find out what the research shows about creatine supplements for muscle mass and cognitive function.
FOLR1 and FOLR2: Transporting Folate, Folinic Acid, and Folic Acid into Cells
Genetic variants in the FOLR1 and FOLR2 genes (folate receptors alpha and beta) can impact folate in the brain and in the immune response.
Migraines: Genes, Root Causes, and Personalized Solutions
Your genes play a role in your susceptibility to migraines. Find out what is going on when you have a migraine and solutions that fit your genes.
Nicotinamide Riboside and NMN: Boosting NAD+ in Aging
Explore the research about how nicotinamide riboside (NR) and NMN are being used to reverse aging. Learn about how your genes naturally affect your NAD+ levels and how this interacts with the aging process.
MTR and MTRR Genes: Vitamin B12, Homocysteine, and Methylation
There are several genes that can influence your absorption, transport, and need for vitamin B12. Some people need higher amounts of B12, and some people thrive on different forms of B12. Take a look at your genetic data to see if you should up your intake of B12.
Multiple Chemical Sensitivity (MCS): Genetics, Causes, and Solutions
Struggling with Multiple Chemical Sensitivity (MCS)? Learn about the connection between genetics, detoxification enzymes, and the olfactory system. Discover how targeting specific genetic variants can help alleviate symptoms.
Riboflavin (Vitamin B2), MTHFR, and Deficiency Symptoms
Riboflavin, or vitamin B2, is an essential cofactor for many biological pathways. Learn how to check your genetic raw data to see if you may need more riboflavin.
Folate Optimization: MTHFR and Fertility
MTHFR variants affect the conversion of folate into the active form. Learn how this can affect you if you are trying to get pregnant.
Blood Pressure, MTHFR, and Riboflavin
The common MTHFR C677T variant increases the relative risk of high blood pressure. Learn how to add more Riboflavin (B2) into your diet to reduce risk.
Estrogen, Histamine, and Mast Cell Connections
Mast cells can be more easily triggered in the presence of high estrogen or estrogen-mimicking compounds. Histamine can also trigger mast cell degranulation. Together, this can cause a lot of symptoms related to mast cell activation.
Arsenic Detoxification and Your Genes
Arsenic exposure occurs via well water, in certain foods, and through breathing. This article covers the pathways the body uses to get rid of arsenic, and it includes information on genetic variants that may impair the detoxification of arsenic.
Root Cause(s) of Depression
Depression can have multiple physiological causes. This article ties together 9 separate articles on depression to simply your genetic search.
CBS Gene Variants and Low Sulfur Diet
Some clinicians recommend a low sulfur diet for people with CBS mutations. Find out what the research shows – and why that recommendation is not backed up. (Member’s article)
MTHFR: Going Beyond C677T and A1298C
The MTHFR C677T and A1298C variants get a lot of press, but they do not give the whole picture of the MTHFR gene. Additional variants are impacting the functionality of the enzyme.
MTHFR, Depression, Anxiety, Symptoms and Treatment
We are all genetically unique, and a common genetic variant in the MTHFR gene causes some people to be more susceptible to having low folate levels. This article explains the research linking MTHFR variants, folate, and depression — and gives you information on how diet or supplements may help.
Vaccines and the MTHFR mutation
A lot of people use the MTHFR variants as a reason not to vaccinate their kids. Is there any science to back this up? See what the research says.
BHMT: Genetic Variants that Impact Methylation
BHMT is involved in homocysteine methylation and impacts the methylation cycle.
DHFR and MTHFR: Folic Acid Metabolism
Methylfolate may be a better option than folic acid if you have certain genetic variants in the MTHFR or DHFR genes.
ME/CFS: Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (and Long Covid?) Genes
Take a look into the science of the lingering effects of viruses, including chronic fatigue syndrome and long-haul viruses.
MTHFR and Migraines
The MTHFR C677T variant increases the risk of migraines. Learn how to check your genetic data and how to mitigate the risk.