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How HMGB1 acts as an alarmin, escalating the inflammatory response to infection and injury

HMGB1 gene: Inflammatory Response Protein and COVID-19

The HMGB1 protein has a unique role in activating the inflammatory response pathways. Increased HMGB1 levels will call up the troops for a big response to an infection. Discover how genetic variants of this protein vary the risk of cancer, inflammation, and sepsis to name a few.